-Buyer who buy for Reseller or want original box please **Tell me** i will sent With Original box and *Not* Open it but may have risk from your customs

-Buyer who **Not Tell Me** Or for personal eating i will sent The Bottle only and *Opened* for safety & avoid customs hold

100% 

Authentic Composition Each capsules of Reduce 15mg contains 
Sibutramine 15mg Description SIBUTRAMINE belong to the category of 
appetite suppressant. The Structural Formula: 
1-(4-chlorophenyl)-N,N-dimethyl-a-(2-methylpropyl)-cyclobutanemethanamine 
Molecular Formula:C17H26ClN Molecular Weight:279.85 g/mol Mechanism 
Of Action Inhibits reuptake of norepinephrine, serotonin, and 
dopamine. May stimulate satiety center in brain, causing appetite 
suppression. Inhibits reuptake of Serotonin(5.H.T) nor adrenaline 
and to a lesser extent, dopamine in Vivo and in vitro M1 and M2 
Metabolite are pharmacologically active and are up to about 
100-fold more potent reuptake inhibitors than sibutramine has no 
effects on dopamine receptors, some thermogenic activity is evident 
at doses of 10mg apparent low abuse potential in humans.Reduce 
(Sibutramine) produce its therapeutic effect by Norepinephrine, 
Serotonin and dopamine reuptake inhibition. Pharmaco Kinetics 
Reduce reaches maximum therapeutic concentration in 1.2hrs. Food 
delays the absorption by 3hrs. Approximately 77% of the single oral 
dose is absorbed. Steady state reached with in 4days. Reduce 
(Sibutramine) is extensively bound and is rapidly and extensively 
distributed into tissue. It undergoes extensive first pas 
metabolism and is primarily by cytochromep4503A4 isoenzyme. 
Approximately 85% of the drug eliminated through urine. Indications 
Management of obesity, including weight loss and maintenance of 
weight loss and should be used in conjugation with a reduced 
calorie diet. Contra Indications Pregnancy and paediatric patients, 
hypersensitivity,patients receiving MAO 
inhibitors,anorexia,nervosa, patients taking other centrally acting 
appetite suppressant drug. Drug Interactions Should not be taken 
with mao inhibitors, and drugs that may raise blood pressure or 
heart rate. Should not be taken along with ephidrine, phenyl 
propanolamine. Adverse Effects Dry mouth,anorexia, 
constipation,insomnia, dizziness. Special Precautions Monitor BP 
regularly when prescribing sibutramine. Dosage Its recommended for 
obese patients with an initial BMI 30kg/m2 or 27kg/m2 in the 
presence of the risk factors(e.g. 
hypertension,diabetes,dyslipidemia).Initially 10mg of sibutramine 
is given once daily with or without food. If there is inadequate 
weight loss, the dose may be titrated after four weeks to a total 
of 15mg once daily. Contraindications and warnings - Do not eat for 
those who have absolute identification of liver disease, kidney 
heart, thyroid - Pregnancy and during lactation. Do not eat. 

PAYMENT METHOD : PAYPAL ONLY

SHIPPING TYPE : SHIPPING VIA AIRMAIL SHIPPING.