Pharmacodynamics. Neurotropic vitamins of group B have a beneficial effect on inflammatory and degenerative diseases of the nerves and musculoskeletal system. They are prescribed to eliminate deficiency states, and in large doses have analgesic properties, improve blood circulation, normalize the functioning of the nervous system and the process of hematopoiesis.
Vitamin B1 is a very important active substance. In the body, it is phosphorylated to form biologically active thiamine diphosphate (cocarboxylase) and thiamine triphosphate (TTP).
Thiamine diphosphate as a coenzyme participates in important functions of carbohydrate metabolism, is of crucial importance in metabolic processes of nervous tissue, affects the conduction of nerve impulses in synapses. With a deficiency of vitamin B 1 in tissues, metabolites accumulate, primarily lactic and pyruvic acids, which leads to various pathological conditions and disorders of the nervous system.
Vitamin B6 in its phosphorylated form (pyridoxal-5?-phosphate – PALP) is a coenzyme of a number of enzymes that interact in the general non-oxidative metabolism of amino acids. Through decarboxylation, they are involved in the formation of physiologically active amines (e.g. adrenaline, histamine, serotonin, dopamine, tyramine), through transamination – in anabolic and catabolic metabolic processes (e.g. glutamate-oxaloacetate transaminase, glutamatepyruvate transaminase, GABA, ?-ketoglutarate transaminase), as well as in various processes of amino acid breakdown and synthesis. Vitamin B6 acts on 4 different sites of tryptophan metabolism. In the process of hemoglobin synthesis, vitamin B6 catalyzes the formation of ?-amino-?-ketoadenic acid.
Vitamin B12 is necessary for cellular metabolism. It affects the function of hematopoiesis (extrinsic anti-anemic factor), participates in the formation of choline, methionine, creatinine, nucleic acids, and has an analgesic effect.
Pharmacokinetics. When administered orally, vitamin B6 and its derivatives are mostly rapidly absorbed in the upper digestive tract by passive diffusion and excreted within 2-5 hours. After parenteral administration, thiamine is distributed in the body. About 1 mg of thiamine is metabolized daily. Metabolites are excreted in the urine. Dephosphorylation occurs in the kidneys. The biological half-life of thiamine is 0.35 hours. Thiamine does not accumulate in the body due to its poor solubility in fats.
Vitamin B6 is phosphorylated and oxidized to pyridoxal-5?-phosphate. In blood plasma, pyridoxal-5?-phosphate and pyridoxal are bound to albumin. It is transported in the form of pyridoxal. To pass through the cell membrane, pyridoxal-5?-phosphate, bound to albumin, is hydrolyzed by LF to pyridoxal.
Vitamin B12 after parenteral administration forms transport protein complexes that are rapidly absorbed by the liver, bone marrow and other organs. Vitamin B12 enters the bile and participates in the enterohepatic circulation, penetrates the placental barrier.
Tablets. for neurological diseases caused by proven deficiency of vitamins B1, B6.
Solution for injection. Neurological diseases of various origins: neuritis, neuralgia, polyneuropathy (diabetic, alcoholic), radicular syndrome, retrobulbar neuritis, facial nerve damage.
Milgamma tablets are taken orally, washed down with a sufficient amount of liquid.
The recommended dose is 1 tablet per day. In individual cases, the dose is increased and used 1 tablet 3 times a day.
The tablets should be taken whole with liquid, after meals.
The duration of the course of treatment is determined by the doctor individually in each case. After the maximum period of treatment (4 weeks), a decision is made to correct and reduce the dose of the drug.